Basic research

Basic research on the body's own active ingredient thiocyanate by Prof. Dr. Axel Kramer and other renowned scientists (excerpt from published documents):

Kramer A (2021) The physiological mode of action of thiocyanate and its influence on hair growth.
Cutting-edge research – Aesthetic Dermatology and Dermatosurgery 2021; pp. 60-65.

Dabas D, Elias RJ, Ziegler GR, Lambert JD (2019) In Vitro Antioxidant and Cancer Inhibitory Activity of a Colored Avocado Seed Extract. Int J Food Sci 2019: 6509421.

Schlorke D, Flemmig J, Gau J (2016) New insights into thiocyanate oxidation by human myeloperoxidase.
Journal of Inorganic Biochemistry, 162, 117-126.

Chandler JD, Day BJ (2015) Biochemical mechanisms and therapeutic potential of pseudohalide thiocyanate in human health.
Free radical research 2015, 49(6): 695-710.

Chandler JD, Day BJ (2012) Thiocyanate: a potentially useful therapeutic agent with host defense and antioxidant properties.
Biochemical pharmacology 2012, 84(11): 1381-1387.

Xulu BA, Ashby MT (2010) Small molecular, macromolecular, and cellular chloramines react with thiocyanate to give the human defense factor hypothiocyanite.
Biochemistry (49), 2068-74.

Han H, Kwon H (2009) Estimated dietary intake of thiocyanate from Brassicaceae family in Korean diet.
J Toxicol Environ Health A (72), 1380-1387.

Xu Y, Szep S, Lu Z (2009) The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases.
Proc Natl Acad Sci USA (106), 20515-19.

Kramer A, Böhland H, Below H (2008) Inorganic thiocyanates.
In: A. Kramer, O. Assadian (eds.): Wallhäuser's Practice of Sterilization, Disinfection, Antiseptics, and Preservation. Stuttgart: Thieme; 2008, 891–4.

Ihalin R, Loimaranta V, Tenovuo J (2006) Origin, structure, and biological activities of peroxidases in human saliva.
Arch Biochem Biophys 2006, 445(2): 261–8.

Paul BD, Smith ML (2006) Cyanide and thiocyanate in human saliva by gas chromatography-mass spectrometry.
J Anal Toxicol (30), 511-515.

Goncalves Salum F, Cherubini M, Amado Eloni A, et al (2006) Histologic evaluation of effect of thiocyanate topical application on hamster cheek pouch.
Clinical Oral Investigations, 10 (3).

Weuffen W, Tirsch Ch, Meffert H, Hiepe-Wegener D (2004) Influence on hair properties.
In: Weuffen W, Decker H (eds) Thiocyanate: a bioactive ion. Törpin: I.S.M.H.; 2004; 309-22.

Decker H (2004) Influencing the conformation of biomolecules.
In: Weuffen W, Decker H (eds) Thiocyanate: a bioactive ion: With orthomolecular character. Törpin: I.S.M.H.; 2004; 191-201.

Rosin M, Kocher T, Bradtke D, Richter G, Kramer A (2002) The effect of a SCN-/H2O2 toothpaste compared to a commercially available triclosan-containing toothpaste on oral hygiene and gingival health – a 6-month home-use study.
J Clin Periodontol 2002; 29:1086 91.

Rosin M, Kocher T, Kramer A (2001) Effects of SCN-/H2O2 combinations in dentifrices on plaque and gingivitis.
J Clin Periodontol 2001, 28: 270-6.

Schultz CP, Ahmed MK, Dawes C, Mantsch HH (1996) Thiocyanate levels in human saliva: Quantification by Fourier transform infrared spectroscopy.
Anal Biochem (240), 7-12.

Kramer A, Weuffen W, Hiepe T, Völzke M, Völzke N, Thürkow B, Jülich WD, Weber A (1996) Promotion of wool production and body mass development in sheep by alimentary thiocyanate supplementation.
Berl Münch Tierärztl Wschr 1996, 109: 419-27.

Sima D, Meffert H, Kramer A, Tiersch Ch, Weuffen W (1995) Hair growth promotion by rhodanide (thiocyanate) - a double-blind study.
Hautnah Dermatologie 1995; 11: 608-11.

Kramer A, Zarbock R, Zöllner H, Weuffen W (1994) Biological significance of thiocyanate,
Journal of Dermatology 180, 182-187.

Kramer A, Zarbock R, Zöllner H, Weuffen W (1994) Influence of age, gender, hair washing and hair condition on the content of thiocyanate as a natural growth factor in human head hair.
Z Dermatol 1994; 180: 182-7.

Weuffen W, Kramer A, Thürkow B, Winetzka H (1994) Influence of dietary thiocyanate supplementation on fur properties in mink (Mustela vision).
Ber. Münch. Tierärztl. Wschr. 1994; 107: 299-302.

Thürkow B, Weuffen W, Kramer A, Below H, Johnson D (1992) On the importance of thiocyanate for healthy human nutrition.
German Food Review 88, 307-313.

Thürkow B, et al (1992) On the treatment of thiocyanate for healthy human nutrition.
German Food Review, 88 (10), 307.

Weuffen W, Kramer A, Below H, Böhland H, Jülich WD, Thürkow B, Burth U (1990) The thiocyanate ion as a physiologically important active substance in living nature.
Pharmacy 1990 45(1): 16–29.

Kramer A, Weuffen W (1990) Importance of thiocyanate for plants, livestock and humans as an endogenous, alimentary or environmental factor.
Know. Z. Univ. Med. R. 39, Issue 1, 8-9.

Kramer A, et al (1990) Influence of thiocyanate on the hair follicle cycle and hair development in humans.
Med. Series, Scientific Z. Ernst-Moritz-Arndt University of Greifswald, 39 17.

Kramer A, Weuffen W, Minnich S, Koch S, Minnch M, Below H, Thürkow B, Meffert H (1990) Promotion of hair development by thiocyanate in the guinea pig.
Dermatol Mschr 1990; 176: 417-20.

Kramer A, Minnich S, Koch S, Minnich M, Below H, Thürkow B, Weuffen W (1990) Influence of thiocyanate on the hair follicle cycle and hair development in the guinea pig.
Scientific Journal of the Ernst-Moritz-Arndt University of Greifswald, Medical Series 39 (1), 17-22.

Pause U, Wiechel P (1990) Influence of different ointment bases on the effectiveness of SCN- in the model of the experimental incision wound in the guinea pig.
Diss Med Fak Univ Greifswald 1990.

Weuffen W, Kramer A, Ambrosius H, et al (1990) On the significance of the endogenous active substance and environmental factor thiocyanate for nonspecific and specific resistance from a hygienic point of view.
Zbl Hyg Umweltmed 189: 473–510.

Michajlovskij N (1990) Thiocyanate as an indicator of indole glucosinolate products in plant foods and its possible significance for carcinogenesis.
Scientific Journal of the Ernst-Moritz-Arndt University of Greifswald, Medical Series, 39 (1), 27-28.

Thürkow B, Schwahn M, Weuffen W (1990) Preliminary study on the thiocyanate content of drinking water.
Scientific Journal of the Ernst-Moritz-Arndt University of Greifswald, Medical Series, 39 (1), 63-66.

Koch S, Kramer A, Kupfer M, Wehner W, Weuffen W (1990) Influence of thiocyanate on bone fracture healing after experimental femoral osteotomy in the guinea pig.
Wiss ZE-M.-Arndt-Univ Greifswald, 1990; Med R 39:22-4.

Mach H, Mach F, Kramer A, Weuffen W (1990) Influence of thiocyanate ions on proliferation and intracellular cAMP content in an E. coli B strain.
Wiss Z EM Arndt-Univ Greifswald, Med R 1990, 39: 9-10.

Zippel C, Weuffen W, Kramer A, Thürkow B, Below H, Wernicke E, Schicke B (1990) Thiocyanate levels in patients with cachexia.
Wiss Z E.-M.-Arndt-Univ Greifswald, Med R 1990, 39: 58-59.

Gromoll K, Ehmke M, Klebingat KJ, Kramer A, Thürkow E, Wiesner M, Weuffen W (1990) Investigations on the thiocyanate content in human ejaculate.
Wiss Z E.-M.-Arndt-Univ Greifswald, Med R 1990, 39: 54-5.

Römer W, Löber G (1990) Influence of thiocyanate ions on cAMP phosphodiesterase in different cell fractions.
Wiss Z. EM-Arndt-Univ Greifswald, Med R 199, 39: 8-9.

Jahn M, Müller R (1990) Influence of thiocyanate on the wound closure reaction of plant tissues.
Scientific Journal of the Ernst-Moritz-Arndt University of Greifswald, Medical Series, 39 (1), 45-47.

Weuffen W, Adam C, Kramer A, Verbeek F, Krohnfeldt J, Riske E, Weuffen C (1990) Influence of different application conditions of KSCN on growth and yield of potatoes.
Wiss Z E.-M.-Arndt-Univ Greifswald, Med R 1990, 39: 42-4.

Weuffen W, Below H, Böhland H, Jülich WD, Kramer A (1990) Recent ideas on the biological mechanism of action of the thiocyanate ion - an introduction to the contributions of the 7th Thiocyanate Conference.
Scientific Journal of the Ernst-Moritz-Arndt University of Greifswald, Medical Series, 39 (1), 5-7.

Koch M, Ramm R (1989) Influence of thiocyanate on wound healing using a model of a primarily sutured and secondarily healing skin wound in the guinea pig.
Diss Academy for Medical Education GDR, 1989.

Jülich WD, Weuffen W (1987) Aspects of the mechanism of action of thiocyanate.
Scientific Journal of the Ernst-Moritz-Arndt University of Greifswald, Medical Series 36 (3-4), 26-30.

Machill G, et al (1987) Effect of thiocyanate on the proliferation of human skin fibroblasts in vitro.
Wiss. Z. Ernst-Moritz-Arndt-University Greifswald, Med. Series 36 (3-4), 72-75.

Weuffen W, Kramer A (1987) On the classification of the thiocyanate effect within life processes and resulting applications.
Scientific Journal of the Ernst-Moritz-Arndt University of Greifswald, Medical Series, 36 (3-4), 5-16.

Kramer A, Weuffen W, Paetzelt H, Lüdde KH, Gross W, Spiegelberger E, Wollmann C, Burmeister C. (1987) Investigations on thiocyanate absorption after episomatic application to guinea pigs.
Wiss ZE-M.-Arndt-Univ Greifswald, Med R 1987, 36: 69-71.

Kramer A, Weuffen W, Adrian V, Adam C, Heinrich U (1987) Investigations on the protective efficacy of sodium thiocyanate against toxic influences (antitoxic thiocyanate effect) on FL cells and cress seeds.
Wiss Z E.-M.Arndt Univ Greifswald, Med R 1987, 36: 75-7.

Kramer A, Kühn M, Burmeister C, Weuffen W (1987) Influence of NaSCN on the peripheral blood count of healthy mice and mice treated with cytostatic doses of cyclophosphamide.
Wiss Z E.-M.-Arndt-Univ Greifswald, Med R. 1987, 36: 63-5.

Kramer A, Weuffen R, Below H, Jülich WD, Weuffen W (1987) Thiocyanate serum levels in guinea pigs as a function of thiocyanate application and immunization.
Wiss Z E.-M.-Arndt-Univ Greifswald, Med R 1987, 36: 66-68.

Weuffen W, Blohm H, Meng W, Thürkow B, Kramer A, Weber A, Bauch KH, Elze P, Petermann K, Ahrens R (1987) Investigations on the protective application of thiocyanate/iodine in calf rearing.
Wiss Z Univ Greifswald Med R 1987, 36: 100-103.

Blohm H, B. Thürkow B, Weuffen W (1987) Protective use of thiocyanate in industrial calf rearing and fattening - summary of own results.
Wiss Z Univ Greifswald, Med R 1987, 36: 93-99.

Thürkow B, Kramer A, Weuffen W, et al (1987) On the nutritional significance of thiocyanate.
Scientific Journal of the Ernst-Moritz-Arndt University of Greifswald, Medical Series, 36 (3-4), 17-20.

Weuffen W, Jahr H, Kiowski S, et al (1987) Interaction of thiocyanate (SCN-) and hydrogen peroxide (H2O2) in nonspecific defense with special reference to phagocytosis.
Scientific Journal of the Ernst-Moritz-Arndt University of Greifswald, Medical Series, 36 (3-4), 39-43.

Kramer A (1985) Test system for determining the tolerance of antimicrobial substances and preparations for episomatic application by in vitro and animal experiments (episomatic test) and toxicohygienic assessment as a component of hospital hygiene tasks.
Habilitation thesis, Medical Faculty, University of Greifswald, 1985.

Weuffen W, Burth U, Müller P, Tirschmann W, Kramer A, Below H (1984) Influence of thiocyanate on growth and resistance properties of plants.
Wiss Z E.-M.-Arndt-Univ Greifswald, Med R 1984, 32: 59-60.

Weuffen W, Ambrosius H, et al (1982) Medical and biological significance of thiocyanates (rhodanides): with 65 figures, 29 formulas and schemes; 107 tables. Berlin: Verl. Volk u. Gesundheit with the specialist articles:
- Redmann K. Influence on biological membranes, p. 74
- Paetzelt H. Influence on transport processes in biological membranes, p. 65.

Kramer A, Weuffen W, Schroeder H, Prott V, Prott P (1979) Behavior of the blood rhodanide level during stress in the guinea pig induced by a third degree burn.
German Health Sciences 1979, 34: 1261-4.

Wood JL (1975) Biochemistry.
In: Newman AA (ed): Chemistry and Biochemistry of Thiocyanic Acid and Its Derivatives. London: Academic Press 1975; 156-221.

Bowler RG (1944) The determination of thiocyanate in blood serum.
Biochem J (38), 385-8.